"Ultra-high dose methylcobalamin promotes nerve health. Recent biochemical evidence suggests that an ultra-high dose of methylcobalamin (methyl-B12) may up-regulate gene transcription and thereby protein synthesis." - Source: Ultra-high dose methylcobalamin promotes nerve regeneration (Department of Neurology, Kyoto University Hospital, Japan.)
"These findings indicate that methyl-B12 promotes the health of nerve terminals." - Source: Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals (Laboratory Animal Research Center, Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.)
"An overall beneficial therapeutic effect was observed in all three groups during the study, and a significant improvement in most of the parameters studied appeared already at the 3rd week of therapy. The greatest change occurred in the group of patients receiving the high dose of benfotiamine." - Source: Effectiveness of different benfotiamine dosage regimens (2nd Department of Internal Medicine, Municipal St. John's Hospital, Budapest, Hungary)
"It is quite clear that benfotiamine is absorbed much better than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 times higher after benfotiamine. The bioavailability is at maximum about 3.6 times as high as that of thiamine." - Source: Pharmacokinetics of thiamine derivatives especially of benfotiamine Intl Journal of Clinical Pharmacology & Therapeutics, 1996 Feb;34(2):47-50.)
"The role of oxidative stress in nerve damage has been extensively studied...Alpha-lipoic acid seems to delay or reverse nerve damage through its multiple antioxidant properties. In clinical trials, 600 mg alpha-lipoic acid has been shown to support nerve function." - Source: Alpha Lipoic Acid abstract (Department of Internal Medicine, Polykliniki General Hospital)
"Alpha-lipoic acid seems to be efficient and safe, improving both clinical manifestations and nerve conduction velocity." - Source: Effects of 3-month treatment with the antioxidant alpha-lipoic acid (G Negrisanu, University of Medicine, Timişoara)
"Treatment with R-Alpha Lipoic Acid over 3 weeks is safe and effective ..." - Source: Alpha Lipoic Acid abstract (D. Ziegler & FA Gries, Research Institute at the Heinrich Heine University, DĂĽsseldorf, Germany)
"Oral treatment with R-Alpha Lipoic Acid for 5 weeks improved nerve symptoms." - Source: Oral Treatment With α-Lipoic Acid (Sydney 2 Trial, Dan Ziegler, 2006)