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Top 5 Nerve Supplements of 2022

Top 5 Nerve Supplements of 2022

A Buyer's Guide To Finding The Best Nerve Supplement to Reduce Nerve Related Discomfort, Tingling, Or Numbness

Updated Tuesday, Sept 20, 2022

Taking a quality nerve support supplement can have a dramatic impact on your nerve health and function.

That’s because as you age - your body undergoes natural changes that can lead to a decline in nerve function. For example, aging of the myelin sheath (a layer protective tissue that insulates nerves) can cause nerve conduction to slow - resulting in decreased sensations, slower reflexes, phantom sensations (ie. tingling), and discomfort.

Age related changes can also impair the release of neurotransmitters that support normal nerve function.

And decreased circulation can also affect nerve health as less blood is delivered to the nerves in your hands and feet - depriving them of the oxygen and nutrients they need to stay healthy.

To make matters worse, age-related decline in nerve function can be amplified if the nerves are damaged by something else (i.e. physical injury, underlying medical conditions, or nutritional deficiencies).

In fact, according to Dr. Kenneth Maiese of Rutgers University, as you age…

“The peripheral nervous system’s response to injury is reduced. When the axon of a peripheral nerve is damaged in younger people, the nerve is able to repair itself as long as its cell body, located in or near the spinal cord, is undamaged. This self-repair process occurs more slowly and incompletely in older people, making older people more vulnerable to injury and disease.”1

But there's good news...

There are a few specific vitamins & nutrients that support your nerves as they age - helping to reduce the effects of aging on nerves and promote healthy nerve function. Which is why finding a quality nerve supplement is so important.

Studies have found that these key vitamins and nutrients play an important role in nerve function and have the ability to:

• Strengthen nerve insulation (i.e. myelin sheath) to protect nerve cells

• Build nerve fiber density (to improve nerve communication)

• Support healthy blood flow (to deliver fresh oxygen and nutrients to nerves)

• Nourish nerves to support proper nerve function

• Reduce occasional aches, discomfort, and weakness

But not all nerve supplements are created equally.

While a high quality supplement can have a big impact on nerve health - there are a lot of shady companies that fill their supplements with cheaper, less effective ingredients (while still charging a premium).

If you’ve tried any of the myriad of nerve supplements and products on the market - you know how difficult it can be to find one that works.

Which is why we’ve compiled months of research for you below to help you make a well-informed decision. We’ll show you exactly what to look for and what to avoid when picking a nerve supplement - and how taking the right one can support your nerves and help reduce occasional aches, discomfort, or weakness.

You’ll also find our top 5 nerve supplements picks - each one vetted by our team - so you can make sure you’re getting the best vitamins & nutrients for your nerves.

What To Look For When Choosing a Nerve Supplement:

There are a lot of nerve supplements out there. To make sure you’re getting a supplement that will actually support nerve function and reduce discomfort, it should meet the following criteria:

Uses the Right Form (And Dosage) of Proven Ingredients

There are specific vitamins & nutrients that have been shown to have a significant effect on nerve health & discomfort. But many of these ingredients come in different forms, some of which aren’t as effective.

That’s why it’s important to find a supplement that uses the right form (and dosage) as the ones in the clinical studies that show them to be beneficial to nerves.

Here are 5 key ingredients to look for in a nerve supplement and how to know if it has the most effective form and dose of each one:

(Click each ingredient below to expand)

Stabilized R-Alpha Lipoic Acid

Alpha Lipoic Acid (ALA) has a powerful effect on nerve health.

In one study, medical professor Dan Ziegler gave R-ALA to 181 patients suffering from nerve discomfort.

In just five weeks, R-ALA improved nerve function and reduced discomfort by up to 52%.2

When picking a nerve supplement, look for one that uses Stabilized R-Alpha Lipoic Acid.

Most supplements use S-Alpha Lipoic Acid. This synthetic version is cheaper to produce, but doesn’t have the same impact on nerves as R-Alpha Lipoic Acid (the naturally occuring form).

Not only does R-ALA absorb up to 12x better than S-ALA - but studies that show it helps reduce occasional nerve discomfort and improve nerve function.

Additionally, make sure they use “Stabilized” R-ALA. Because Alpha Lipoic Acid is a very unstable molecule, exposure to light or heat can cause it to quickly deteriorate (making it less effective).

Stabilized R-ALA undergoes a process to protect its stability and ensure maximum potency and benefit.

For best results, we recommend a daily dose of 300-600mg of R-ALA.

Vitamin B12 (as Methylcobalamin)

To protect nerves fibers, your body produces a coating known as the Myelin sheath. This coating transfers communication across your nervous system. When your myelin sheath is healthy, nerve cells need less power to talk with your brain.3

Vitamin B-12 is one of the few nutrients that can directly support a healthy Myelin sheath around nerve fibers.

Unfortunately, B12 has notoriously poor absorption rates.

Most supplements contain a cheap and hard-to-digest form of Vitamin B12 named Cyanocobalamin.4 The structure of cyanocobalamin makes it hard for your body to absorb it - so very little makes it into the bloodstream to support your nerves.

But there's a more effective form of B12 called Methylcobalamin - which is more easily absorbed.

Not only that - but several studies have revealed that high doses of this form of B12 can help:

> Promote regeneration of the myelin sheath5

> Reduce drug-induced nerve discomfort.6

> And more…

For best results, we recommend a daily dose of 4mg (4,000mcg) or higher of Vitamin B12 as methylcobalamin.

Vitamin B1 (as Benfotiamine)

Vitamin B1 is necessary for the growth, development, and function of cells and is one of four B vitamins (B1, B2, B6, B12) that - according to the European Journal Of Pain - supports optimal nerve function.7

Many nerve supplements contain the common form of vitamin B1 called thiamine. This transforms carbs into energy and powers your nervous system.

But your body has a hard time absorbing thiamine. When you take normal vitamin B1, you don't get the nutrients your body needs to support good nerve health. When B1 is not properly absorbed it passes right out of your body in your urine, without doing you a bit of good.

For better absorption of this important vitamin, we recommend Vitamin B1 as Benfotiamine.

Studies have shown benfotiamine can increase Thiamine levels in your bloodstream, FIVE TIMES more than normal B1...8 9

This potent form of Vitamin B1 has also been shown to…

> Absorb 360% better than normal vitamin B1, so your nerve cells can feel better faster10

> Improve communication between nerve cells11

> Help you enjoy a better quality of life by turning down the volume on the nerve signals flooding your brain…

Vitamin B6 (as Pyridoxine HCI)

According to a study in Advances in Nutrition journal, Vitamin B6 improves nerve fiber density in your feet.12

The more nerve fiber density you have, the better tiny nerve cells can send crystal clear messages to your brain…which will help to reduce “misfires” that can cause discomfort.

More importantly…

Researchers have found that when Vitamin B6 is taken together with B2 and B12 - they work synergistically to contribute to a healthy nervous system.13

One important thing to remember is that unlike other vitamins - more is NOT better with B6. Too much vitamin B6 can actually be toxic to your nerves. Never exceed 100mg of B6/day.

To be safe, we recommend a low dose of around 6-8mg of B6, which is enough to support nerve health while maintaining a safe buffer to prevent overuse, which can harm nerves.

Vitamin B2 (Riboflavin)

Vitamin B2 acts as a “booster” to the vitamins we’ve mentioned so far. That’s because it trains your body to absorb vitamins & nutrients better.

In fact, if you’re low in Vitamin B2, it can disrupt your body’s ability to absorb nutrients like B-6, Folate, Niacin, and iron, according to researchers at Oregon State University.14

Best of all - when you take all of the B vitamins listed above - they work together to have a more powerful effect on nerve health.

The American Journal of Pharmacological Sciences says, “combining (B1, B6, and B12) produces a synergistic effect that, apart from participating in vital body functions, can help treat other health issues such as discomfort.”15

One study from the European Journal of Pain, showed that B vitamins can support optimal nerve function”.16

In a collaboration study, 234 doctors treated a combined 1,149 patients using B-vitamin combination. This time 69% of the test subjects showed signs of improvement in THREE WEEKS!17

In a double-blind, randomized, controlled study – scientists from Germany also combined Vitamin B1, B6, and B12. To their surprise they watched the speed of nerve communication significantly increase.18

Transparent Labeling

The supplement should have a detailed ingredient label that shows every ingredient present, including the form of each ingredient used. The form is often put in parentheses next to the ingredient’s common name. For example: "Vitamin B12 (Methylcobalamin)"

Good Reputation

There are a lot of “fly by night” supplements out there. They pop up online, aggressively sell their products, make unrealistic claims with little to no evidence to back them up, and have terrible customer service. These companies usually only stay in business for a short time before their reputation catches up to them.

When shopping for a nerve supplement, research the company. Check their Better Business Bureau rating, read customer reviews from a trusted 3rd party service like Google or TrustPilot, and check to see how long they’ve been in business.

Satisfaction Guarantee

Any reputable company will have a reasonable & simple return or refund policy. Lets face it, supplements won’t work for everyone - and if a company doesn’t give you the ability to easily get a refund after trying out their product, it means they don’t have a lot of confidence in the product itself.

Outstanding Customer Service

A reputable company should have knowledgeable customer support reps that are experts on the product and nerve health in general. Too many companies farm out their customer service to “phone banks” in foreign countries with reps that know little to nothing about nerve health.

Check the company reviews on Google or TrustPilot to see what customers are saying about their customer support. And make sure the company is upfront about how to reach them (i.e. phone number, email, contact forms) for support.

What To Avoid:

Now that you know what to look for, here are a few common tactics companies use to cut costs at your expense. Watch out for the following when buying your next nerve supplement:

Knock Off Ingredients

Avoid supplements that use cheap knock-offs of key ingredients in their formula. Make sure they're using the best form of each vitamin or ingredient for optimal absorption. Refer to the ingredient list above to see the most effective form of the vitamins & nutrients we recommend.

Low or Ineffective Doses of Active Ingredients

Watch out for supplements that use low and ineffective doses of the ingredients mentioned above. Many companies will put just enough of certain ingredients in their formula to be able to list it as an ingredient on the label - but it may not be enough to have a meaningful effect.

Unproven Ingredients

Watch out for products that make big claims about new and exciting ingredients without research to back them up. A reputable company should cite multiple independent, peer-reviewed studies to back up any claims about their ingredients.

Top 5 Nerve Supplements Of 2022

Top 5 Nerve Supplements Of 2022

We spent months carefully researching and analyzing the most popular nerve supplements on the market today. Based on a thorough review of each supplement’s ingredients, customer reviews, Better Business Bureau Ratings, and product guarantee - here is a list of the top 5 nerve supplements (in our opinion)!

1. Nerve Renew Advanced Nerve Support Formula

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*Results are based on Nerve Renew's Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


Uses optimal forms of B vitamins & Alpha Lipoic Acid for best results

High dose of Vitamin B12 to support nerve regeneration

10 proven ingredients make this the most complete nerve supplement on the market

1 year guarantee with fast & easy refund process (no restocking fees)

Average customer rating of 4.3 out of 5 stars

Over 3,000 customer reviews (between their website & Amazon)

Knowledgeable & friendly US-based customer service team

A+ Rating with the Better Business Bureau


Only available online

High demand, occasionally sells out

The Bottom Line:

Nerve Renew earns high marks in every category.

Unlike many of its competitors, Nerve Renew doesn’t cut any corners with its ingredients. In fact, it’s the most complete formula we found in our research - loaded with the most effective form and dosage of 10 different ingredients to boost nerve function and reduce discomfort.

That includes Vitamin B12 (methylcobalamin), Vitamin B1 (Benfotiamine), Vitamin B6, Vitamin B2, Stabilized R-ALA, Vitamin D, and a proprietary blend of 4 calming herbs to quiet and soothing screaming nerves.

On top of its high quality ingredients, Nerve Renew has a one-year satisfaction guarantee - so you can order with confidence knowing you can get your money back if it doesn’t work.

But if its customer reviews are any indication - you won’t need to take advantage of their guarantee. Nerve Renew boasts an average 4.3 out of 5 star rating - with over 4,000 customer reviews!

Finally, Nerve Renew is an established leader in nerve health.

Founded in 2010, they’ve been delivering quality products and top-notch customer service for over a decade. Their products and service have earned them an A+ Rating with the Better Business Bureau, making them a trusted partner for people looking for solutions to their nerve discomfort.


This Doctor-Recommended Slipper Reduces Nerve Pain & Numbness in as Little as 14 Days!

2. Nerve Regen Formula

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*Results are based on Nerve Renew's Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


Uses optimal forms of B vitamins & Alpha Lipoic Acid

Contains Acetyl-l-carnitine, which may be beneficial to nerve health

365 day guarantee


Only 2,000 mcg Vitamin B12 (half of what’s in Nerve Renew)

Only 154 customer reviews with an avg rating of 3.5 out of 5 stars (at the time of this article publishing)

No feverfew herbal extract (a potent herb that acts as a pain reliever)

Not Accredited with Better Business Bureau (BBB also notes a pattern of complaints with this company)

The Bottom Line:

Nerve Regen seems to be a fairly good product, with a few flaws.

We like that their formula contains the optimal forms of Vitamin B12, B1, and Stabilized R-Alpha Lipoic Acid. They also added Acetyl-L-Carnitine, an ingredient with some promising potential for nerve health & discomfort.

The biggest concern with their ingredients is the low dosage of Vitamin B12, at only 2,000mcg. As one of the most important ingredients, it would be better if there were double that. Most studies show only ultra-high doses of B12 (as methylcobalamin) have a meaningful effect on nerves.

The other red flags with Nerve Regen come from their customer ratings and Better Business Bureau report. With only 154 customer ratings, it appears they may be new in the nerve supplement space. Their average star rating of 3.5/5 is decent, but well below other nerve supplements.

Finally, we were concerned about their “F” rating and lack of accreditation on the Better Business Bureau’s website. There were also 3 alerts posted to the company overview page on the BBB website with notes that the BBB has noticed a pattern of complaints about this company.

3. Dr. Danielle Alpha Lipoic Acid

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*Results are based on Nerve Renew's Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


High dose of R-Alpha Lipoic Acid (300mg)

2,500+ customer reviews with solid star rating (4.6/5)


Uses a mix of R-ALA & S-ALA (some studies suggest that S-ALA may inhibit the therapeutic benefits of R-ALA on nerves)

This is only an Alpha Lipoic Acid supplement. Does not contain other vitamins & nutrients that can support nerve health & reduce discomfort.

Refunds only accepted within 60 days of purchase (it typically takes 3-6 months for most to notice results with nerve supplements, so a 60-day return window seems to short)

15% restocking fee on orders over $200

The Bottom Line:

We love that Dr. Danielle’s Alpha Lipoic Acid supplement has a great customer rating and a strong dose of Alpha Lipoic Acid (550mg)!

This would be a great supplement to add to your regimen if you’re already taking a high quality B-vitamin supplement.

The only downside is that instead of using only R-Alpha Lipoic Acid (the most optimal form of ALA), this supplement has a mix of 250mg of S-ALA (synthetic form of Alpha Lipoic Acid) and 300mg R-ALA.

The problem with using a mix is that S-ALA may actually inhibit the most essential properties of R-ALA.19

According to a 2019 peer-reviewed analysis of various studies on ALA, “The R enantiomer of ALA shows better pharmacokinetic parameters, including increased bioavailability as compared to its S enantiomer.” The analysis further states that S-ALA “stops the important activities of R-ALA, e.g., their interaction with genes, enzymes and proteins.”20

4. Nerve Control 911

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*Results are based on Nerve Renew's Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


Over 700 customer reviews

Unique ingredients


Limited scientific support for some ingredients

No B vitamins or Alpha Lipoic Acid

Only a 90 Day Money Back Guarantee

3.6 out of 5 star customer rating

“B-” rating on Better Business Bureau (with 33 complaints)

The Bottom Line:

This is an interesting nerve supplement that seems to work for some people. It consists of 5 “plant-based” ingredients: Marshmallow Root, Passionflower, Corydalis Powder, Prickly Pear, and California Poppy Seed.

Their Amazon listing claims these ingredients help support and soothe the central and somatosensory systems. And while we’re intrigued by the ingredients, we found the scientific evidence to back the ingredients claims to be lacking.

For example, one the evidence page for their primary ingredient (Marshmallow Root), they don’t link to any peer-reviewed studies. Instead, the supporting evidence is from RXlist.com and Healthline.com - which should not be considered as proof. In our own search, we were unable to find any credible studies on the effectiveness of this ingredient for nerve health.

We also found the cost to be quite high given the lack of proven ingredients like Vitamin B12, B1, B6, and Alpha Lipoic Acid.

5. Nervive Nerve Health Supplement

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*Results are based on Nerve Renew's Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.


Available in select stores

Good customer rating


Uses less effective forms of Vitamin B12 & B1 (don’t absorb as well)

Not enough Vitamin B12 (only 24mcg…studies show nerves need ultra-high dose of around 4,000mcg to repair nerve insulation)

No Vitamin B2 (which can help improve absorption of other vitamins)

3.6 out of 5 star customer rating

Could not find a satisfaction guarantee/return policy

The Bottom Line:

On the surface, Nervive appears to be a good choice - and its reviews would suggest that customers like it. In addition to some quality ingredients, it is available in select stores throughout the United States.

But a careful analysis reveals a few red flags to be aware of before you run out and buy it.

The first area of concern is that it uses the cheaper and less effective forms of Vitamins B12 (cyanocobalamin) and B1 (Thiamine). Most clinical studies showing the benefits of these vitamins for nerve health use B12 as Methylcobalamin and B1 as Benfotiamine. That’s likely because these forms are more easily absorbed by the body.

In addition to using the cheaper form of B12 - the dosage is only 24mcg. That’s significantly lower than the “utlra-high” doses of B12 (4,000mcg or more) that studies suggest are required to have any real benefit on sensitive nerves.

This formula also lacks Vitamin B2 - which can help train your body to absorb other nutrients better.

Lastly, while it has a great customer rating and over 3,000 reviews, a careful analysis found that a number of reviewers indicated they received the product as part of a promotion in exchange for a review. This could skew the rating to be slightly higher than it would be otherwise.

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The information contained within this site is not intended as a substitute for professional medical advice. If you have, expect to have, or suspect you may have any medical condition, you are urged to consult with a health care provider. These statements have not been evaluated by the Food and Drug Administration.

These products are not intended to diagnose, treat, cure, or prevent any diseases or medical conditions. Results are based on Nerve Renew Ranking System and do not necessarily reflect typical results from the use of these products. Please visit product websites for more information.

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